![]() Smaller uptake values were found in the putamen contralateral to the side with more affected limbs. In all PD patients, FMT uptake was decreased in the posterior putamen regardless of predominant motor symptoms and disease duration. FMT uptake in the subregions of the striatum was analyzed using semi-automated software for region-of-interest demarcation on co-registered magnetic resonance images. Motor symptoms were measured with the Unified Parkinson's Disease Rating Scale (UPDRS). PD was diagnosed based on the UK Brain Bank criteria by two experts on movement disorders. We assessed 101 patients with PD and 19 healthy volunteers. The aim of the present study was to determine the relationship between subregional aromatic l-amino acid decarboxylase (AADC) activity in the striatum and the cardinal motor symptoms of PD using high-resolution positron emission tomography (PET) with an AADC tracer, 6-fluoro-ʟ- m-tyrosine (FMT). In idiopathic Parkinson's disease (PD) the clinical features are heterogeneous and include different predominant symptoms.
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